ICGEB New Delhi has 25 Research Groups. The Component also has a flourishing PhD programme in association with the Jawaharlal Nehru University (JNU) and at any given time has up to 100 PhD students.  ICGEB PIs have obtained research grants from national funding agencies as well as extra-mural funds from international agencies, such as The Wellcome Trust, European Malaria Vaccine Initiative, European Commission, International Aids Vacine Initiative, National Institute of Health, Bill & Melinda Gates Foundation, Dupont and Pepsico.

An innovative collaboration programme has also been established with the Emory Global Vaccine Centre that focuses on the development of vaccines against diseases such as tuberculosis and malaria.